How the Evidence Room grades confidence
How the Evidence Room works: We state a hypothesis, gather the strongest published evidence for and against it, and grade our confidence using a fixed rubric. Every study is cited and linked, limitations included. When the evidence is mixed, we say so. When new evidence changes the picture, we update the verdict and log the change. This is how we'd want the science explained to us.
The confidence rubric
Confidence follows the evidence through this fixed rubric — never the reverse. One verdict that looks graded-on-a-curve discounts every other verdict in the room.
- High
- Multiple independent RCTs or systematic reviews pointing the same direction, mechanism understood.
- Moderate
- Consistent evidence with smaller cohorts, heterogeneity, or few head-to-head trials.
- Emerging
- Strong mechanistic evidence with early or indirect clinical support.
Who reviews
Every hypothesis is reviewed by Mark Katakowski, PhD, Chief Scientific Officer. Study cards are signed off against full texts before publish. Verdicts can move down as well as up.
How often we update
We review every verdict at least quarterly, and sooner when a trial, systematic review, or safety signal would move the grade. Verdicts can move down as well as up.