Clinical Articles

Numerous studies reported better results when the mesenchymal stem cells were used in co-culture with other cells or used in scaffolds. Mesenchymal stem cells were also found to have an immune-modulatory role, which can improve surgical outcome.

This study shows the key positive finding that this treatment approach demonstrated both safety and clinical benefit in patients with chronic discogenic low back pain, with no adverse events reported during the 1-year follow-up period.

MSC therapy is safe and effective in treating IS by improving the neurological deficits, motor function and daily life quality of patients.

Changes in neurological deficits and improvements in function were compared between two groups for 1 year after symptom onset. Patients treated with autologous MSCs showed significant improvement in both cognition and mobility.

This study provides strong evidence that autologous hematopoietic stem cell transplantation offers superior long-term clinical outcomes compared to two of the most effective current disease-modifying therapies for relapsing multiple sclerosis, particularly in terms of preventing relapses and maintaining sustained clinical benefit over a 5-year follow-up period.

Stem cell-based approaches can induce poststroke recovery via mechanisms, such as neuronal replacement, promotion of angiogenesis, induction of brain plasticity, reduction of cell death, or immunomodulation.

MSCs offer a promising emerging therapy for patients with IBD due to their immunosuppressive properties, ability to migrate to areas of injury, and demonstration of colonic healing.

Reports summarized here suggest significant potential for the use of mesenchymal stem cells in osteoarthritis.

No alternative intervention strategies match, or even get close to, the clinical outcome achieved in a considerable number of patients treated with autologous stem cell transplantation. We propose that this patient group should be identified, diligently informed and offered the possible benefits of an extended period of insulin-free and burden-free survival,

Cell-based therapies including pluripotent and multipotent adult stem cells show proven repair and regeneration potential and are being considered as a remedy for diabetic complications, which are the most prominent reason for high mortality among diabetic patients. They may also provide a long-term cure for diabetes and its complications.

Results of this study suggest that administration of adipose-derived stem cells (ADSCs) may be associated with improvements in cognitive as well as biochemical measurements for patients diagnosed with Alzheimer Disease.

Intramyocardial delivery of stem cells is more complicated than intracoronary administration, but it is safe and may provide better therapeutic outcomes.