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Clinical
1 min read
Pmc
Suppression of Oct4 by Germ Cell Nuclear Factor Restricts Pluripotency and Promotes Neural Stem Cell Development in the Early Neural Lineage
New findings reveal that the germ cell nuclear factor (GCNF) plays a crucial role in neural stem cell development by suppressing Oct4, a key gene for maintaining pluripotency. This regulation is vital for the transition of primitive neural stem cells to definitive ones, potentially unlocking new avenues for regenerative therapies in neurodegenerative diseases.
Oct4 SuppressionNeural Stem Cells