HomeArticlesAestheticsRandomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
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Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy

Source:PubMed
Published:2021

Unlocking Youth: How Stem Cells Are Revolutionizing Anti-Aging with Forever Labs

At Forever Labs, we’re dedicated to empowering you to age on your terms by preserving your body’s most powerful regenerative tool: your own mesenchymal stem cells (MSCs). Through our cutting-edge autologous stem cell banking service, we store your young, vibrant bone marrow-derived stem cells at their peak potency for future therapeutic use. A groundbreaking study published in the Journal of Cosmetic Dermatology showcases the exciting potential of stem cell-derived therapies for skin rejuvenation, aligning perfectly with our mission to help you maintain vitality as you age. Let’s explore this research and how Forever Labs is leading the charge in regenerative anti-aging solutions.

The Study: Stem Cells and Skin Rejuvenation

The study, titled “Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy,” involved 25 participants seeking to combat visible signs of aging skin. Conducted by dermatology experts, including Young In Lee, and published in June 2021, the research focused on enhancing the results of ablative fractional laser (AFL) treatment—a popular procedure that stimulates collagen production but can cause temporary inflammation. The researchers tested whether a topical moisturizer containing human adipocyte-derived mesenchymal stem cell-conditioned media (ADSC-CM) combined with 2% niacinamide could boost anti-aging outcomes post-laser.

How It Worked

In this double-blind, randomized, vehicle-controlled trial, participants received AFL treatment on both sides of their faces. One side was treated with the active moisturizer (ADSC-CM plus niacinamide), while the other received a plain vehicle cream. Over three weeks, patients applied the products daily. Outcomes were measured using advanced tools like a digital photography analyzer to assess wrinkle depth and melanin levels—key indicators of aging and pigmentation irregularities. Patient satisfaction and the investigator’s global aesthetic improvement scale (GAIS) provided additional insights into the treatment’s impact.

The Results

The findings were remarkable:

  • Wrinkle Reduction: The side treated with ADSC-CM and niacinamide showed significantly reduced wrinkle depth compared to the control side.

  • Improved Pigmentation: Melanin levels, which contribute to age spots and uneven skin tone, were notably lower on the active treatment side.

  • Higher Satisfaction: Patients reported greater satisfaction with the treated side, and investigators noted superior aesthetic improvements via the GAIS.

To support these clinical outcomes, the study included in vitro experiments with human keratinocytes (skin cells). When exposed to UVB irradiation (mimicking sun damage), cells treated with ADSC-CM and niacinamide showed:

  • Reduced levels of pro-inflammatory cytokines, which accelerate aging.

  • Decreased expression of matrix metalloproteinases (MMP-1 and MMP-2), enzymes that degrade collagen.

  • Increased production of Type 1 collagen, essential for firm, youthful skin.

A cell scratch assay, simulating wound healing, further confirmed the regenerative potential of the treatment, highlighting its ability to promote skin repair.

Why This Matters for Forever Labs

At Forever Labs, we specialize in banking bone marrow-derived MSCs, which share similar regenerative properties to the adipocyte-derived MSCs used in this study. While the research utilized conditioned media—a secretome rich in growth factors, cytokines, and extracellular vesicles—our service preserves your own MSCs for direct therapeutic applications. Imagine banking your stem cells in your 20s or 30s, when they’re at their most potent, through our minimally invasive procedure at foreverlabs.com. As you age, these cells could be thawed and used in personalized treatments, such as:

  • Topical applications like those in the study for enhanced skin rejuvenation.

  • Injections or other advanced regenerative therapies for skin, joints, or overall vitality.

Unlike off-the-shelf products, autologous stem cells minimize rejection risks and maximize efficacy, making them ideal for personalized anti-aging strategies. The study’s use of niacinamide, a form of vitamin B3 known for its skin-brightening and barrier-strengthening properties, also suggests that combining natural compounds with stem cell technology could be a game-changer in dermatology.

The Bigger Picture: Stem Cells and Longevity

This research is part of a broader trend in regenerative medicine, where stem cells are transforming not just medical treatments but also aesthetic and longevity solutions. At Forever Labs, we’ve seen growing interest in stem cell banking for cosmetic purposes, from reducing wrinkles to enhancing overall vitality. Our cryogenic storage ensures your cells remain viable for decades, ready for emerging therapies like those explored in this trial. By banking your MSCs today, you’re investing in a future where personalized treatments could address skin aging, joint health, immune function, and more.

Why Bank with Forever Labs?

The study’s findings validate the transformative potential of MSC-derived therapies, showing measurable improvements in skin texture, tone, and resilience without invasive procedures beyond the initial laser. At Forever Labs, we’re committed to making this potential accessible. Our process is simple:

  1. Collection: A minimally invasive procedure harvests your bone marrow MSCs.

  2. Cryopreservation: We store your cells at ultra-low temperatures to preserve their potency.

  3. Future Use: Your cells are ready for personalized therapies as regenerative medicine advances.

By partnering with researchers and clinicians, Forever Labs stays at the forefront of stem cell applications, ensuring your banked cells can be used in cutting-edge treatments.

Take Control of Your Aging Journey

The Journal of Cosmetic Dermatology study demonstrates how stem cell-conditioned media, enhanced by niacinamide, can supercharge laser therapy for anti-aging results. At Forever Labs, we’re here to help you harness your body’s regenerative power. Don’t wait for wrinkles to deepen or vitality to fade—visit foreverlabs.com to learn how stem cell banking can preserve your youthful essence for tomorrow’s breakthroughs. Your future self deserves it.

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