Reviving Hair Growth: Adipose-Derived Stem Cells and Microneedling for Alopecia with Forever Labs

At Forever Labs, we are dedicated to helping you combat hair loss and maintain your youthful appearance by preserving your mesenchymal stem cells (MSCs) for future regenerative therapies. Our autologous stem cell banking service at foreverlabs.com allows you to store your young, potent bone marrow-derived MSCs, ensuring they are ready for personalized treatments as regenerative medicine advances. A recent study published in Stem Cell Research & Therapy explores the potential of adipose-derived stem cell constituent extract (ADSCCE) combined with microneedling for treating androgenetic alopecia (AGA), offering exciting insights for hair restoration. Let’s dive into this research and see how Forever Labs is positioned to support these advancements.

The Study: ADSCCE and Microneedling for Androgenetic Alopecia

The study, titled “Therapeutic effects of adipose-derived stem cell constituent extract on androgenetic alopecia with preliminary microneedling,” was published in June 2023 by researchers including Sang Yeoup Lee and colleagues. It investigated the efficacy and safety of ADSCCE, a protein-rich extract derived from adipose-derived stem cells (ADSCs), when applied topically with microneedling in patients with AGA, the most common form of hair loss driven by genetic and hormonal factors. Microneedling, a minimally invasive technique, creates microchannels in the scalp to enhance topical treatment absorption, while ADSCCE contains growth factors and cytokines that promote hair follicle regeneration.

Study Design and Methodology

This single-arm, prospective study involved 20 patients (16 men, 4 women) with AGA, aged 20–60 years. Participants underwent six treatment sessions at two-week intervals, where microneedling was performed on the scalp followed by topical application of ADSCCE. Outcomes were assessed through:

• Phototrichogram Analysis: Measuring hair density (hairs/cm²) and hair shaft diameter at baseline, 12 weeks, and 24 weeks.

• Patient-Reported Outcomes: Evaluating subjective improvements in hair growth and satisfaction via questionnaires.

• Safety Assessments: Monitoring adverse events like scalp irritation or inflammation.

• Molecular Analysis: Examining scalp biopsies for expression of hair growth-related genes (e.g., VEGF, Wnt/β-catenin pathway).

Key Findings

The results were promising:

• Increased Hair Density: At 12 weeks, hair density significantly increased from baseline (mean increase of 16.2 hairs/cm²), with further improvements by 24 weeks (mean increase of 22.7 hairs/cm²).

• Thicker Hair Shafts: Hair shaft diameter improved significantly, contributing to fuller-looking hair.

• Patient Satisfaction: 85% of participants reported noticeable improvements in hair volume and scalp coverage, with high satisfaction scores.

• Molecular Effects: Biopsies showed upregulated expression of VEGF and Wnt/β-catenin pathway genes, indicating enhanced hair follicle regeneration and angiogenesis.

• Safety Profile: No serious adverse events were reported; mild, transient scalp redness resolved quickly.

These findings suggest that ADSCCE combined with microneedling is a safe and effective treatment for AGA, promoting hair growth and thickness by stimulating follicle regeneration and scalp vascularization.

Why This Matters for Forever Labs

At Forever Labs, we specialize in banking bone marrow-derived MSCs, which share regenerative properties with the adipose-derived MSCs used to produce ADSCCE in this study. While the research utilized ADSC-derived extracts, bone marrow MSCs can similarly produce growth factors, cytokines, and exosomes with hair regeneration potential. By banking your MSCs through our minimally invasive procedure at foreverlabs.com, you preserve a resource that could be used to create personalized regenerative therapies for hair loss. Imagine banking your MSCs in your 20s or 30s, when they are at their peak potency. Years later, if you face AGA, your banked cells could be thawed to produce extracts like ADSCCE or used in other regenerative protocols to stimulate hair follicles and restore hair density. Autologous therapies, derived from your own cells, minimize rejection risks and maximize efficacy, aligning with the study’s focus on safe, effective interventions.

The Broader Impact: Stem Cells and Hair Restoration

Androgenetic alopecia affects millions, impacting confidence and quality of life. Current treatments like minoxidil or finasteride often yield limited or temporary results. The Stem Cell Research & Therapy study highlights a regenerative approach: ADSCCE with microneedling promotes hair growth by enhancing follicle regeneration and scalp health. This aligns with Forever Labs’ vision of using stem cells to address cosmetic and age-related concerns proactively. Our advanced cryogenic storage ensures your MSCs remain viable for decades, positioning you to benefit from emerging therapies like those in this study. As research advances, we anticipate broader applications of MSC-derived therapies, from hair restoration to skin rejuvenation and beyond, making stem cell banking a forward-thinking investment in your appearance and vitality.

Take Charge of Your Hair Health

The Stem Cell Research & Therapy study demonstrates that ADSCCE combined with microneedling can significantly improve hair density and thickness in AGA patients. At Forever Labs, we’re here to help you harness your body’s regenerative potential. Don’t let hair loss define your future—visit foreverlabs.com to learn how stem cell banking can preserve your MSCs for tomorrow’s breakthroughs. Restore your confidence and age on your terms with Forever Labs.